Case 228: Mueller-Weiss Disease

Answer to case of the month #129. Mueller-Weiss syndrome.

Mueller-Weiss syndrome is a rare entity related to adult-onset spontaneous osteonecrosis of the navicular. It is a painful and debilitating illness, which is more frequent in women and can be either unilateral or bilateral. It was first described by Walther Mueller in 1927, who believed this condition was due to chronic compression of the navicular from the adjacent bones. In 1929, Konrad Weiss...

Open triple fusion versus TNC arthrodesis in the treatment of Mueller-Weiss disease

BACKGROUND Mueller-Weiss disease is a rarely diagnosed deformity where the navicular bone undergoes spontaneous osteonecrosis in adults. Until now, there is no widely accepted operative treatment for this unusual disease. We aimed to compare clinical and radiological outcomes between the open triple fusion and talonavicular-cuneiform arthrodesis for Mueller-Weiss disease of stage 4. METHODS D...

Flatfoot in Müller-Weiss syndrome: a case series

INTRODUCTION Spontaneous osteonecrosis of the navicular bone in adults is a rare entity, known as Müller-Weiss syndrome. We report here on our experience with six patients with Müller-Weiss syndrome accompanied by flatfoot deformity, but on a literature search found no reports on this phenomenon. Because the natural history and treatment are controversial, an understanding of how to manage this...

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The World Health Organization has identified hypercholesterolemia to be one of the major symptoms encompassing the metabolic syndrome. Moreover, epidemiologic evidence indicates that lowbirth-weight offspring are at greater risk of developing the metabolic syndrome. Previous work in our laboratory demonstrated that maternal protein restriction (MPR) results in impaired fetal growth and hypercho...

Weiss Knives